The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder

Ann Neurol. 2016 Jul;80(1):13-23. doi: 10.1002/ana.24659. Epub 2016 Apr 30.

Abstract

Neuroblastoma is a childhood cancer derived from cells of neural crest origin. The hallmarks of its enigmatic character include its propensity for spontaneous regression under some circumstances and its association with paraneoplastic opsoclonus, myoclonus, and ataxia. The neurodevelopmental underpinnings of its origins may provide important clues for development of novel therapeutic and preventive agents for this frequently fatal malignancy and for the associated paraneoplastic syndromes. Ann Neurol 2016;80:13-23.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Disease Progression
  • Humans
  • Molecular Targeted Therapy
  • Neoplasm Regression, Spontaneous
  • Neural Crest / growth & development
  • Neural Crest / pathology*
  • Neuroblastoma / complications
  • Neuroblastoma / drug therapy
  • Neuroblastoma / etiology*
  • Neuroblastoma / pathology
  • Neurodevelopmental Disorders / complications
  • Neurodevelopmental Disorders / etiology*
  • Neurodevelopmental Disorders / pathology
  • Opsoclonus-Myoclonus Syndrome / immunology
  • Paraneoplastic Syndromes, Nervous System / complications
  • Paraneoplastic Syndromes, Nervous System / etiology