Abstract
Luffolide (4) is a minor metabolite of the sponge Luffariella sp. from Palau. The structure of luffolide was determined by single crystal X-ray analysis. Luffolide is relatively unstable and undergoes a complex cyclization reaction to give the hexacyclic products 5 and 6. Luffolide (4) has some of the anti-inflammatory properties of manoalide (1): this may help to define the chemical reaction between manoalide (1) and phospholipase A2.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Inflammation / drug therapy
-
Magnetic Resonance Spectroscopy
-
Mice
-
Molecular Conformation
-
Molecular Structure
-
Phospholipases A / antagonists & inhibitors
-
Phospholipases A2
-
Porifera / analysis*
-
Spectrophotometry, Infrared
-
Terpenes* / pharmacology
-
Terpenes* / therapeutic use
-
X-Ray Diffraction
Substances
-
Terpenes
-
luffolide
-
manoalide
-
Phospholipases A
-
Phospholipases A2