Disseminated Panton-Valentine Leukocidin-Positive Staphylococcus aureus infection in a child

Arch Argent Pediatr. 2016 Apr;114(2):e75-7. doi: 10.5546/aap.2016.eng.e75. Epub 2016 Apr 1.
[Article in English, Spanish]

Abstract

Panton-Valentine leukocidin (PVL) is an exotoxin that is produced by many strains of Staphylococcus aureus, and an important virulence factor. A PVL-positive S. aureus infection leads to rapid and severe infections of soft tissue and necrotizing pneumonia in healthy adolescents, and has a high mortality. This case report included a 12-year-old male patient who admitted for fever, respiratory distress and hip pain and was identified with necrotizing pneumonia with septic pulmonary embolism, psoas abscess, cellulitis and osteomyelitis. The PVL positive methicillin-sensitive S. aureus (MSSA) was isolated in the patient blood culture.

La leucocidina de Panton-Valentine (LPV) es una exotoxina producida por muchas cepas de Staphylococcus aureus, y un importante factor de virulencia. Una infección por S. aureus positivo para LPV deriva en infecciones rápidas y graves de partes blandas y neumonía necrosante en adolescentes sanos, y la tasa de mortalidad es elevada. Presentamos el caso de un paciente de 12 años hospitalizado por fiebre, dificultad respiratoria y coxalgia en el que se identificó neumonía necrosante con embolia pulmonar séptic absceso del psoas, celulitis y osteomielitis. En el hemocultivo del paciente se aisló S. aureus sensible a la meticilina (SASM) positivo para LPV.

Keywords: Necrotizing pneumonia; Panton-Valentine leukocidin; Sepsis; Staphylococcus aureus.

Publication types

  • Case Reports

MeSH terms

  • Bacterial Toxins / analysis*
  • Child
  • Community-Acquired Infections
  • Exotoxins / analysis*
  • Humans
  • Leukocidins / analysis*
  • Male
  • Staphylococcal Infections / diagnosis*
  • Staphylococcus aureus

Substances

  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin