Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling

Haematologica. 2016 Jun;101(6):e249-53. doi: 10.3324/haematol.2015.138172. Epub 2016 Apr 14.
No abstract available

Keywords: Krüppel-like factor 4; NOTCH signaling; chronic lymphocytic lymphoma; inactivation; inhibition; promoter DNA-methylation.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Methylation
  • DNA, Neoplasm* / genetics
  • DNA, Neoplasm* / metabolism
  • Female
  • Humans
  • Kruppel-Like Factor 4
  • Kruppel-Like Transcription Factors* / genetics
  • Kruppel-Like Transcription Factors* / metabolism
  • Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell* / metabolism
  • Leukemia, Lymphocytic, Chronic, B-Cell* / pathology
  • Male
  • Neoplasm Proteins* / genetics
  • Neoplasm Proteins* / metabolism
  • Promoter Regions, Genetic*
  • Receptors, Notch* / genetics
  • Receptors, Notch* / metabolism
  • Signal Transduction*

Substances

  • DNA, Neoplasm
  • KLF4 protein, human
  • Kruppel-Like Factor 4
  • Kruppel-Like Transcription Factors
  • Neoplasm Proteins
  • Receptors, Notch