Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population

Mihoko Shimada-Sugimoto; Takeshi Otowa; Taku Miyagawa; Seik-Soon Khor; Yosuke Omae; Licht Toyo-Oka; Nagisa Sugaya; Yoshiya Kawamura; Tadashi Umekage; Akinori Miyashita; Ryozo Kuwano; Hisanobu Kaiya; Kiyoto Kasai; Hisashi Tanii; Yuji Okazaki; Katsushi Tokunaga; Tsukasa Sasaki

doi:10.1038/hgv.2016.1

Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population

Hum Genome Var. 2016 Feb 25:3:16001. doi: 10.1038/hgv.2016.1. eCollection 2016.

Authors

Mihoko Shimada-Sugimoto¹, Takeshi Otowa², Taku Miyagawa³, Seik-Soon Khor¹, Yosuke Omae¹, Licht Toyo-Oka¹, Nagisa Sugaya⁴, Yoshiya Kawamura⁵, Tadashi Umekage⁶, Akinori Miyashita⁷, Ryozo Kuwano⁷, Hisanobu Kaiya⁸, Kiyoto Kasai⁹, Hisashi Tanii¹⁰, Yuji Okazaki¹¹, Katsushi Tokunaga¹, Tsukasa Sasaki¹²

Affiliations

¹ Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
² Graduate School of Clinical Psychology, Teikyo Heisei University Major of Professional Clinical Psychology , Tokyo, Japan.
³ Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
⁴ Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University , Kanagawa, Japan.
⁵ Department of Psychiatry, Shonan Kamakura General Hospital , Kanagawa, Japan.
⁶ Division for Environment, Health and Safety, The University of Tokyo , Tokyo, Japan.
⁷ Department of Molecular Genetics, Center for Bioresources, Brain Research Institute, Niigata University , Niigata, Japan.
⁸ Panic Disorder Research Center, Warakukai Med. Corp. , Tokyo, Japan.
⁹ Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
¹⁰ Department of Psychiatry, Institute of Medical Life Science, Graduate School of Medicine, Mie University , Mie, Japan.
¹¹ Tokyo Metropolitan Matsuzawa Hospital , Tokyo, Japan.
¹² Department of Physical and Health Education, Graduate School of Education, The University of Tokyo , Tokyo, Japan.

Abstract

We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*13:02 (rs4759997; P=5.02×10(-6), odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*13:02.