A Novel EGFR(C797) Variant Detected in a Pleural Biopsy Specimen from an Osimertinib-Treated Patient Using a Comprehensive Hybrid Capture-Based Next-Generation Sequencing Assay

J Thorac Oncol. 2016 Sep;11(9):e105-7. doi: 10.1016/j.jtho.2016.04.005. Epub 2016 Apr 13.

Authors

Roopika Menon¹, Judith Müller², Petra Schneider², Sotirios Lakis², Kenneth Thress³, Jürgen Wolf⁴, Lukas Heukamp², Johannes M Heuckmann², Frank Griesinger⁵

Affiliations

¹ NEO New Oncology AG, Cologne, Germany. Electronic address: menon@newoncology.com.
² NEO New Oncology AG, Cologne, Germany.
³ Translational Science, Oncology iMED, AstraZeneca, Waltham, Massachusetts.
⁴ Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany.
⁵ Department of Hematology and Oncology, Pius Hospital, Oldenburg, Germany.

PMID: 27086175
DOI: 10.1016/j.jtho.2016.04.005

No abstract available

Publication types

Case Reports

MeSH terms

Acrylamides
Adenocarcinoma / drug therapy
Adenocarcinoma / genetics
Adenocarcinoma / pathology
Aniline Compounds
Antineoplastic Agents / adverse effects
Biopsy
Drug Resistance, Neoplasm / genetics*
ErbB Receptors / genetics*
High-Throughput Nucleotide Sequencing / methods*
Humans
Lung Neoplasms / drug therapy
Lung Neoplasms / genetics*
Lung Neoplasms / pathology
Male
Middle Aged
Mutation*
Piperazines / adverse effects*
Pleural Neoplasms / chemically induced
Pleural Neoplasms / genetics*
Pleural Neoplasms / secondary

Substances

Acrylamides
Aniline Compounds
Antineoplastic Agents
Piperazines
osimertinib
EGFR protein, human
ErbB Receptors