Powder-based 3D printing for bone tissue engineering

G Brunello; S Sivolella; R Meneghello; L Ferroni; C Gardin; A Piattelli; B Zavan; E Bressan

doi:10.1016/j.biotechadv.2016.03.009

Powder-based 3D printing for bone tissue engineering

Biotechnol Adv. 2016 Sep-Oct;34(5):740-753. doi: 10.1016/j.biotechadv.2016.03.009. Epub 2016 Apr 13.

Authors

G Brunello¹, S Sivolella², R Meneghello³, L Ferroni⁴, C Gardin⁵, A Piattelli⁶, B Zavan⁷, E Bressan⁸

Affiliations

¹ University of Padova, Department of Neurosciences, Section of Dentistry, Via Giustiniani 2, 35129 Padova, Italy. Electronic address: giulia-bru@libero.it.
² University of Padova, Department of Neurosciences, Section of Dentistry, Via Giustiniani 2, 35129 Padova, Italy. Electronic address: stefano.sivolella@libero.it.
³ University of Padova, Department of Management and Engineering, Stradella S. Nicola 3, 36100 Vicenza, Italy. Electronic address: roberto.meneghello@unipd.it.
⁴ University of Padova, Department of Biomedical Sciences, Via Ugo Bassi 58/B, 35131 Padova, Italy. Electronic address: letizia.ferroni@unipd.it.
⁵ University of Padova, Department of Biomedical Sciences, Via Ugo Bassi 58/B, 35131 Padova, Italy. Electronic address: chiara.gardin@unipd.it.
⁶ University of Chieti-Pescara, Department of Medical, Oral and Biotechnological Sciences, Via dei Vestini 31, 66100 Chieti, Italy. Electronic address: apiattelli@unich.it.
⁷ University of Padova, Department of Biomedical Sciences, Via Ugo Bassi 58/B, 35131 Padova, Italy. Electronic address: barbara.zavan@unipd.it.
⁸ University of Padova, Department of Neurosciences, Section of Dentistry, Via Giustiniani 2, 35129 Padova, Italy. Electronic address: eriberto.bressan@unipd.it.

PMID: 27086202
DOI: 10.1016/j.biotechadv.2016.03.009

Abstract

Bone tissue engineered 3-D constructs customized to patient-specific needs are emerging as attractive biomimetic scaffolds to enhance bone cell and tissue growth and differentiation. The article outlines the features of the most common additive manufacturing technologies (3D printing, stereolithography, fused deposition modeling, and selective laser sintering) used to fabricate bone tissue engineering scaffolds. It concentrates, in particular, on the current state of knowledge concerning powder-based 3D printing, including a description of the properties of powders and binder solutions, the critical phases of scaffold manufacturing, and its applications in bone tissue engineering. Clinical aspects and future applications are also discussed.

Keywords: 3D printing; Additive manufacturing technologies; Binder; Bone; Depowdering; Powder; Scaffold; Sintering.

Publication types

Review

MeSH terms

Bone Substitutes*
Bone and Bones* / cytology
Bone and Bones* / physiology
Humans
Printing, Three-Dimensional*
Tissue Engineering*
Tissue Scaffolds*

Substances

Bone Substitutes