Development of an in vitro test battery model based on liver and colon cancer cell lines to discriminate PCB mixtures by transcription factors gene expression analysis

Toxicol In Vitro. 2016 Aug:34:204-211. doi: 10.1016/j.tiv.2016.04.009. Epub 2016 Apr 19.

Authors

Laura Stecca¹, Sabrina Tait¹, Federica Corrado², Mauro Esposito², Alberto Mantovani¹, Cinzia La Rocca³

Affiliations

¹ Dpt. Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.
² Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute, 2, 80055 Portici (NA), Italy.
³ Dpt. Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. Electronic address: cinzia.larocca@iss.it.

PMID: 27105732
DOI: 10.1016/j.tiv.2016.04.009

No abstract available

Keywords: Dioxin-like PCBs; Gene expression; In vitro model; Mixtures; Non-dioxin-like PCBs.

MeSH terms

Cell Line, Tumor
Cell Survival / drug effects
Colonic Neoplasms / genetics*
Gene Expression Regulation, Neoplastic / drug effects*
Humans
Liver Neoplasms / genetics*
Polychlorinated Biphenyls / toxicity*
Receptors, Cytoplasmic and Nuclear / genetics*
Transcription Factors / genetics

Substances

Receptors, Cytoplasmic and Nuclear
Transcription Factors
Polychlorinated Biphenyls