Mapping the Spectrum of Gene Expression Responses

Michael Pargett; John G Albeck

doi:10.1016/j.cels.2016.04.005

Mapping the Spectrum of Gene Expression Responses

Cell Syst. 2016 Apr 27;2(4):221-2. doi: 10.1016/j.cels.2016.04.005. Epub 2016 Apr 27.

Authors

Michael Pargett¹, John G Albeck²

Affiliations

¹ Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.
² Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA. Electronic address: jgalbeck@ucdavis.edu.

PMID: 27135533
DOI: 10.1016/j.cels.2016.04.005

Abstract

How does one transcription factor generate distinct, diverse expression patterns? Porter et al. reveal that the dynamics of p53 localization and the degradation rates of its target mRNAs are key.

Publication types

Comment

MeSH terms

Chromosome Mapping
Gene Expression Profiling
Gene Expression Regulation*
RNA, Messenger
Transcription Factors / genetics*
Transcription, Genetic
Tumor Suppressor Protein p53 / genetics

Substances

RNA, Messenger
Transcription Factors
Tumor Suppressor Protein p53