Internal limiting membrane translocation for refractory macular holes

Br J Ophthalmol. 2017 Mar;101(3):377-382. doi: 10.1136/bjophthalmol-2015-308299. Epub 2016 May 4.

Abstract

Background/aims: Closure is more difficult to achieve in macular holes that remain open following a previous unsuccessful pars plana vitrectomy (PPV). We present our results with the internal limiting membrane (ILM) translocation technique that is used to optimise outcomes in refractory macular holes.

Methods: A prospective, interventional, case series was conducted. 12 eyes of 12 consecutive patients with incomplete sealing of the macular hole (open and type 2 closure) after a previous PPV with ILM peeling were included. Measured baseline parameters included best-corrected visual acuity (BCVA) and macular hole smallest diameter, base diameter and height. Surgeries were performed by harvesting a fragment of the ILM near the vascular arcades and subsequently placing it inside the hole. Postoperative measured outcomes included macular hole status, foveal contour, outer retina integrity, BCVA and surgery-related complications.

Results: Anatomic closure occurred in 11 of 12 eyes (91%). This technique elicited a statistically significant improvement in BCVA (p=0.008). Mean BCVA was 20/400 at study baseline and 20/160 at final follow-up. However, less than 16.7% of cases had a final BCVA of ≥20/63.

Conclusion: The ILM translocation technique seems to facilitate persistent idiopathic macular hole closure, where primary surgery with PPV and ILM peeling failed.

Keywords: Macula; Retina; Treatment Surgery; Vitreous.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Basement Membrane / surgery*
  • Epiretinal Membrane / surgery
  • Female
  • Humans
  • Male
  • Prospective Studies
  • Retinal Perforations / pathology
  • Retinal Perforations / physiopathology
  • Retinal Perforations / surgery*
  • Visual Acuity / physiology
  • Vitrectomy / methods*