Actin Dynamics and HIV-1 Entry

Sergi Padilla-Parra; Michael L Dustin

doi:10.1016/j.molmed.2016.03.007

Actin Dynamics and HIV-1 Entry

Trends Mol Med. 2016 May;22(5):354-356. doi: 10.1016/j.molmed.2016.03.007. Epub 2016 Apr 14.

Authors

Sergi Padilla-Parra¹, Michael L Dustin²

Affiliations

¹ Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK; Wellcome Trust Human Genetics, Cellular Imaging Core, University of Oxford, Oxford, UK. Electronic address: spadilla@well.ox.ac.uk.
² The Kennedy Institute of Rheumatology, University of Oxford, Headington, Oxford OX3 7BN, UK. Electronic address: michael.dustin@kennedy.ox.ac.uk.

PMID: 27151391
DOI: 10.1016/j.molmed.2016.03.007

Abstract

Cortical F-actin plays important roles during HIV-1 infection. A recent paper in Cell highlights the involvement of F-actin in enhancing dendritic cell (DC)-mediated HIV-1 infection of T cells. Such a critical mechanism of HIV-1 trans-enhancement between human DCs and T cells had not been analyzed in molecular detail before this work.