[Modification of blood coagulation by the anti-arrhythmia drug prajmalium bitartrate in vivo]

Z Kardiol. 1989 Feb;78(2):130-3.
[Article in German]

Abstract

We studied the effects of prajmaliumbitartrate (PBT, Neo-Gilurytmal, Giulini Pharma, Hannover, FRG), an antiarrhythmic drug on some parameters of blood coagulation in patients. PBT, 20 mg given three times a day, significantly prolonged template bleeding time and ex vivo thrombus formation time in a modified Chandler's loop. Ex vivo platelet aggregation using different agonists and tests of the plasmatic coagulation system remained unchanged.

Publication types

  • English Abstract

MeSH terms

  • Ajmaline / analogs & derivatives*
  • Arrhythmias, Cardiac / blood
  • Arrhythmias, Cardiac / drug therapy*
  • Bleeding Time*
  • Blood Coagulation Tests*
  • Humans
  • Middle Aged
  • Platelet Aggregation / drug effects*
  • Platelet Count / drug effects
  • Platelet Function Tests*
  • Prajmaline / therapeutic use*

Substances

  • Ajmaline
  • Prajmaline