Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy

Xiumei Hong; Christine Ladd-Acosta; Ke Hao; Ben Sherwood; Hongkai Ji; Corinne A Keet; Rajesh Kumar; Deanna Caruso; Xin Liu; Guoying Wang; Zhu Chen; Yuelong Ji; Guanyun Mao; Sheila Ohlsson Walker; Tami R Bartell; Zhicheng Ji; Yifei Sun; Hui-Ju Tsai; Jacqueline A Pongracic; Daniel E Weeks; Xiaobin Wang

doi:10.1016/j.jaci.2016.01.056

Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy

J Allergy Clin Immunol. 2016 Sep;138(3):908-911.e9. doi: 10.1016/j.jaci.2016.01.056. Epub 2016 Apr 25.

Authors

Xiumei Hong¹, Christine Ladd-Acosta², Ke Hao³, Ben Sherwood⁴, Hongkai Ji⁴, Corinne A Keet⁵, Rajesh Kumar⁶, Deanna Caruso¹, Xin Liu⁷, Guoying Wang¹, Zhu Chen¹, Yuelong Ji¹, Guanyun Mao⁸, Sheila Ohlsson Walker⁹, Tami R Bartell¹⁰, Zhicheng Ji⁴, Yifei Sun⁴, Hui-Ju Tsai¹¹, Jacqueline A Pongracic⁶, Daniel E Weeks¹², Xiaobin Wang¹³

Affiliations

¹ Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
² Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
³ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
⁴ Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
⁵ Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md.
⁶ Division of Allergy and Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
⁷ Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Ill.
⁸ Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md; Department of Preventive Medicine, School of Environmental Science & Public Health, Wenzhou Medical University, Wenzhou, China.
⁹ Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md; Institute for Interdisciplinary Salivary Bioscience Research, Arizona State University, Tempe, Ariz; The Johns Hopkins School of Education, Baltimore, Md.
¹⁰ Mary Ann & J. Milburn Smith Child Health Research Program, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
¹¹ Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Ill; Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
¹² Departments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa.
¹³ Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md; Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address: xwang82@jhu.edu.

Abstract

We demonstrates that DNA methylation alterations at multiple genes, including those in the TH₁-TH₂ pathways and some novel genes, are associated with cow's milk allergy (CMA), which shed new light on the epigenetic underpinnings of CMA.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Cattle
Child, Preschool
DNA Methylation / genetics*
Female
Genome-Wide Association Study
Humans
Immunoglobulin E / genetics
Male
Milk Hypersensitivity / genetics*

Substances

Immunoglobulin E

Abstract

Publication types

MeSH terms

Substances

Grants and funding