Securing a future for responsible neuromodulation in children: The importance of maintaining a broad clinical gaze

Eur J Paediatr Neurol. 2017 Jan;21(1):49-55. doi: 10.1016/j.ejpn.2016.04.019. Epub 2016 May 24.

Abstract

Aim: This perspective paper provides an overview of several key tensions and challenges within the social context of neuromodulation, and it suggests a means of securing the future of paediatric neuromodulation in light of these.

Results: Tensions and challenges relate to: the considerable clinical and economic need for new therapies to manage neurological diseases; significant commercial involvement in the field; funding pressures; public perceptions (particularly unrealistic expectations); and the emerging Responsible Research and Innovation initiative. This paper argues that managing these challenges and tensions requires that clinicians working within the field adopt what could be called a broad clinical gaze. This paper will define the broad clinical gaze, and it will propose several ways in which a broad clinical gaze can be - and indeed is being - operationalised in recent advances in neuromodulation in children. These include the use of multidisciplinary and interdisciplinary clinical team structures, the adoption of clinical assessment tools that capture day-to-day functionality, and the use of patient registries.

Conclusion: By adopting a broad clinical gaze, clinicians and investigators can ensure that the field as a whole can responsibly and ethically deliver on its significant clinical potential.

Keywords: Bioethics; Deep brain stimulation; Ethics; Patient-centred medicine; Responsible research and innovation.

Publication types

  • Review

MeSH terms

  • Adult
  • Attitude of Health Personnel
  • Brain / physiopathology*
  • Child
  • Deep Brain Stimulation / ethics
  • Epilepsy / physiopathology
  • Epilepsy / therapy
  • Ethics, Medical
  • Humans
  • Interdisciplinary Communication
  • Intersectoral Collaboration
  • Movement Disorders / physiopathology
  • Movement Disorders / therapy
  • Nervous System Diseases / physiopathology*
  • Nervous System Diseases / therapy*
  • Neuronal Plasticity / physiology*
  • Patient-Centered Care / ethics
  • Philosophy, Medical
  • Risk Assessment / ethics
  • Translational Research, Biomedical / ethics