L1CAM: Cell adhesion and more

Prog Histochem Cytochem. 2016 Aug;51(2):25-32. doi: 10.1016/j.proghi.2016.05.001. Epub 2016 May 24.

Abstract

L1CAM is a cell adhesion molecule of the immunoglobulin superfamily which was originally discovered as a major player in the development of the nervous system. L1CAM was demonstrated to have prognostic value in different cancers and to be a promising target for anti-cancer therapy. Here we overview the present data on L1CAM structure and function, regulation of its expression, role in cancer and therapeutic potential.

Keywords: Cancer; Cell adhesion; Ig-like domains; L1CAM.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Cell Adhesion / drug effects
  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Epithelial-Mesenchymal Transition / genetics
  • Fibronectins / chemistry
  • Fibronectins / genetics
  • Fibronectins / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immunoglobulin Domains / genetics
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Neural Cell Adhesion Molecule L1 / antagonists & inhibitors
  • Neural Cell Adhesion Molecule L1 / chemistry
  • Neural Cell Adhesion Molecule L1 / genetics*
  • Neural Cell Adhesion Molecule L1 / metabolism
  • Neurons / metabolism*
  • Neurons / pathology
  • Prognosis
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / metabolism
  • Signal Transduction

Substances

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Fibronectins
  • Neural Cell Adhesion Molecule L1
  • RNA, Small Interfering