Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)

Amany Shabaiek; Nour El-Hoda Ismael; Samar Elsheikh; Hebat Allah Amin

doi:10.3889/oamjms.2016.018

Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study)

Open Access Maced J Med Sci. 2016 Mar 15;4(1):17-21. doi: 10.3889/oamjms.2016.018. Epub 2016 Jan 21.

Authors

Amany Shabaiek¹, Nour El-Hoda Ismael², Samar Elsheikh², Hebat Allah Amin¹

Affiliations

¹ Egyptian Forensic Medicine Authority, Pathology Department, Cairo, Egypt.
² Faculty of Medicine, Kasr El- Aini, Pathology Department, Cairo, Egypt.

Abstract

Background: Many immunohistochemical markers have been used in the postmortem detection of early myocardial infarction.

Aim: In the present study we examined the role of Heart-type fatty acid binding protein (H-FABP), in the detection of early myocardial infarction.

Material and methods: We obtained samples from 40 human autopsy hearts with/without histopathological signs of ischemia.

Results: All cases of definite and probable myocardial infarction showed a well-defined area of H-FABP depletion. All of the control cases showed strong H-FABP expression, except two markedly autolysed myocardial samples that showed affected antigenicity.

Conclusion: Thus, we suggest H-FABP as being one of the valuable tools facing the problem of postmortem detection of early myocardial infarction/ischemia, but not in autolysis.

Keywords: H-FABP; MI; detection myocardial infarction; immunohistochemistry; sudden cardiac death.