PTHrP, its receptor, and protein kinase A activation in osteosarcoma

Carl R Walkley; Mannu K Walia; Patricia W Ho; T John Martin

doi:10.4161/23723548.2014.965624

PTHrP, its receptor, and protein kinase A activation in osteosarcoma

Mol Cell Oncol. 2014 Dec 31;1(4):e965624. doi: 10.4161/23723548.2014.965624. eCollection 2014 Oct-Dec.

Authors

Carl R Walkley¹, Mannu K Walia¹, Patricia W Ho¹, T John Martin¹

Affiliation

¹ St. Vincent's Institute of Medical Research and Department of Medicine; St. Vincent's Hospital; University of Melbourne ; Fitzroy, VIC, Australia.

Abstract

In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.

Keywords: PKA; PTHR1; PTHrP; osteosarcoma.