XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle

Mol Cell Oncol. 2014 Oct 29;2(1):e964622. doi: 10.4161/23723548.2014.964622. eCollection 2015 Jan-Mar.

Abstract

There is currently immense interest in understanding the biological consequences of aberrant necroptosis. The recently uncovered role for X-linked inhibitor of apoptosis protein (XIAP) in blocking tumor necrosis factor-dependent necroptosis explains, at least in part, the systemic hyperinflammatory syndrome XLP-2. However, it also points to rather unexpected differences between XIAP and the related proteins baculoviral IAP repeat containing 2 and 3 (cIAP1/2).

Keywords: RIP3; XIAP; XLP-2; cIAP1; cIAP2; cell death; inflammation; necroptosis.