1 The Faculty of Medicine, University of Melbourne, Melbourne, VIC, Australia; Department of Anesthesia and Intensive Care, Azienda Ospedaliera Dei Colli,V Monaldi, Naples, Italy; Department of Medical Sciences "M. Aresu," University of Cagliari, Cagliari, Italy; Department of Pharmacology and Anesthesiology, University Hospital of Padova, Padova, Italy; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.