Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome

J Allergy Clin Immunol. 2016 Oct;138(4):1210-1213.e5. doi: 10.1016/j.jaci.2016.04.020. Epub 2016 May 13.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Genes, Dominant
  • HEK293 Cells
  • Humans
  • Job Syndrome / genetics*
  • Job Syndrome / immunology
  • Job Syndrome / metabolism*
  • Mutant Proteins / chemistry
  • Mutant Proteins / genetics
  • Mutant Proteins / immunology
  • Mutant Proteins / metabolism
  • Mutation*
  • Phosphorylation / genetics
  • Protein Multimerization / genetics
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / genetics
  • Recombinant Proteins / immunology
  • Recombinant Proteins / metabolism
  • STAT3 Transcription Factor / chemistry
  • STAT3 Transcription Factor / genetics*
  • STAT3 Transcription Factor / metabolism*

Substances

  • Mutant Proteins
  • Recombinant Proteins
  • STAT3 Transcription Factor
  • STAT3 protein, human