Longitudinal associations among asthma control, sleep problems, and health-related quality of life in children with asthma: a report from the PROMIS(®) Pediatric Asthma Study

Zheng Li; Lindsay A Thompson; Heather E Gross; Elizabeth A Shenkman; Bryce B Reeve; Darren A DeWalt; I-Chan Huang

doi:10.1016/j.sleep.2015.12.003

Longitudinal associations among asthma control, sleep problems, and health-related quality of life in children with asthma: a report from the PROMIS(®) Pediatric Asthma Study

Sleep Med. 2016 Apr:20:41-50. doi: 10.1016/j.sleep.2015.12.003. Epub 2016 Jan 6.

Authors

Zheng Li¹, Lindsay A Thompson², Heather E Gross³, Elizabeth A Shenkman⁴, Bryce B Reeve⁵, Darren A DeWalt⁶, I-Chan Huang⁷

Affiliations

¹ College of Nursing and Health Professions, Valparaiso University, Valparaiso, IN, USA.
² Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.
³ Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁴ Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville, FL, USA.
⁵ Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁶ Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁷ Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA. Electronic address: i-chan.huang@stjude.org.

Abstract

Objectives: Few studies have investigated the complex relationship among asthma control, sleep problems, and health-related quality of life (HRQOL) among children with asthma. This study aimed to test the longitudinal effect of asthma control status on asthma-specific HRQOL through the mechanism of nighttime sleep quality and daytime sleepiness.

Methods: The Patient-Reported Outcomes Measurement Information System (PROMIS(®)) Pediatric Asthma Study included 229 dyads of asthmatic children and their parents with two years of follow-up for assessing the change in asthma control, sleep problems, and asthma-specific HRQOL. The Asthma Control and Communication Instrument was used to measure asthma control status. Nighttime sleep quality assessment was based on difficulty falling asleep and getting up, and sleep disturbance. The Iowa Pediatric Daytime Sleeping Scale was used to assess daytime sleepiness. The PROMIS Asthma Impact Scale was used to measure asthma-specific HRQOL. Multilevel structural equation modeling was performed to quantify the direct and indirect effects of asthma control status on asthma-specific HRQOL through nighttime sleep quality and daytime sleepiness.

Results: Poorer asthma control status was directly associated with lower asthma-specific HRQOL at within-subject and between-subject levels (p < 0.05); however, effects of asthma control on asthma-specific HRQOL were indirectly influenced through daytime sleepiness at the within-subject level (p < 0.05), and through nighttime sleep quality and daytime sleepiness at the between-subject level (p < 0.05).

Conclusions: Asthma control status is associated with asthma-specific HRQOL, and this association is mediated by nighttime sleep quality and daytime sleepiness. Clinicians should address sleep problems related to asthma control to improve HRQOL for asthmatic children.

Keywords: Asthma control; Children; Daytime sleepiness; Health-related quality of life; Multilevel structural equation modeling; Nighttime sleep quality.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Asthma / complications
Asthma / therapy*
Child
Female
Humans
Longitudinal Studies
Male
Quality of Life*
Sleep Wake Disorders* / psychology
Surveys and Questionnaires

Abstract

Publication types

MeSH terms

Grants and funding