Polydopamine Hollow Nanoparticle Functionalized with N-diazeniumdiolates as a Nitric Oxide Delivery Carrier for Antibacterial Therapy

Dongsik Park; Jihoon Kim; Yeong Mi Lee; Junghong Park; Won Jong Kim

doi:10.1002/adhm.201600150

Polydopamine Hollow Nanoparticle Functionalized with N-diazeniumdiolates as a Nitric Oxide Delivery Carrier for Antibacterial Therapy

Adv Healthc Mater. 2016 Aug;5(16):2019-24. doi: 10.1002/adhm.201600150. Epub 2016 Jun 22.

Authors

Dongsik Park^{1

2}, Jihoon Kim^{1

2}, Yeong Mi Lee^{1

2}, Junghong Park^{1

2}, Won Jong Kim^{1

2}

Affiliations

¹ Center for Self-Assembly and Complexity, Institute for Basic Science (IBS), Pohang, 37673, South Korea.
² Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

PMID: 27331379
DOI: 10.1002/adhm.201600150

Abstract

A biocompatible nitric oxide (NO) delivery nanoplatform, whose structure is a hollow nanoparticle composed of polydopamine backbone and diazeniumdiolates functional groups, is developed for antibacterial therapy. This platform liberates high NO quantitis and exerts the antibacterial activity with excellent biocompatibility thus being promising for treating bacterial infections.

Keywords: antibacterials; biocompatibility; nitric oxide; polydopamine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents* / chemistry
Anti-Bacterial Agents* / pharmacology
Azo Compounds* / chemistry
Azo Compounds* / pharmacology
Drug Carriers* / chemistry
Drug Carriers* / pharmacology
Nanoparticles / chemistry*
Nitric Oxide* / chemistry
Nitric Oxide* / pharmacology

Substances

Anti-Bacterial Agents
Azo Compounds
Drug Carriers
diazeniumdiolate
Nitric Oxide