Rotavirus infection and histo-blood group antigens in the children hospitalized with diarrhoea in China

Clin Microbiol Infect. 2016 Aug;22(8):740.e1-3. doi: 10.1016/j.cmi.2016.06.007. Epub 2016 Jun 23.

Abstract

To explore the association between rotavirus (RV) infection and histo-blood group antigens (HBGAs), a cross-sectional study was conducted in children hospitalized with diarrhoea in China from November 2014 to February 2015. In total, 424 sets of stool, saliva and buccal cell samples were collected. For the 125 RV-negative samples, 92% (104/125) were secretors/partial secretors, 8% (10/125) were non-secretors. Among the 299 RV-positive samples, 277 were P[8] and 22 were P[4]. All P[4] and P[8] positive individuals were secretors/partial secretors except for one P[8] (0.3%, 1/299), which was a non-secretor. These findings indicate that P[8] and P[4] RVs preferably infect secretors/partial secretors (p <0.001).

Keywords: Epidemiological study; Histo-blood group antigens; Non-secretor; Rotavirus infection; Secretor.

MeSH terms

  • Blood Group Antigens* / blood
  • Child
  • Child, Preschool
  • China / epidemiology
  • Cross-Sectional Studies
  • Diarrhea / blood*
  • Diarrhea / epidemiology
  • Diarrhea / virology*
  • Female
  • Genotype
  • Hospitalization*
  • Humans
  • Male
  • Odds Ratio
  • Population Surveillance
  • Rotavirus Infections / blood*
  • Rotavirus Infections / epidemiology
  • Rotavirus Infections / virology*
  • Rotavirus* / genetics

Substances

  • Blood Group Antigens