Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines

J Immunol. 2016 Aug 15;197(4):1221-30. doi: 10.4049/jimmunol.1501565. Epub 2016 Jun 29.

Abstract

Aluminum salt (alum) adjuvants have been used for many years as adjuvants for human vaccines because they are safe and effective. Despite its widespread use, the means by which alum acts as an adjuvant remains poorly understood. Recently, it was shown that injected alum is rapidly coated with host chromatin within mice. Experiments suggested that the host DNA in the coating chromatin contributed to alum's adjuvant activity. Some of the experiments used commercially purchased DNase and showed that coinjection of these DNase preparations with alum and Ag reduced the host's immune response to the vaccine. In this study, we report that some commercial DNase preparations are contaminated with proteases. These proteases are responsible for most of the ability of DNase preparations to inhibit alum's adjuvant activity. Nevertheless, DNase somewhat reduces responses to some Ags with alum. The effect of DNase is independent of its ability to cleave DNA, suggesting that alum improves CD4 responses to Ag via a pathway other than host DNA sensing.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Alum Compounds / pharmacology*
  • Animals
  • Antigens / immunology
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / drug effects
  • CD8-Positive T-Lymphocytes / immunology
  • DNA / immunology
  • Deoxyribonucleases* / chemistry
  • Deoxyribonucleases* / immunology
  • Deoxyribonucleases* / pharmacology
  • Drug Contamination
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Lymphocyte Activation / drug effects
  • Lymphocyte Activation / immunology*
  • Mass Spectrometry
  • Mice
  • Mice, Inbred C57BL
  • Vaccines / immunology*

Substances

  • Adjuvants, Immunologic
  • Alum Compounds
  • Antigens
  • Vaccines
  • aluminum sulfate
  • DNA
  • Deoxyribonucleases