Minimal basilar membrane motion in low-frequency hearing

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4304-10. doi: 10.1073/pnas.1606317113. Epub 2016 Jul 12.

Abstract

Low-frequency hearing is critically important for speech and music perception, but no mechanical measurements have previously been available from inner ears with intact low-frequency parts. These regions of the cochlea may function in ways different from the extensively studied high-frequency regions, where the sensory outer hair cells produce force that greatly increases the sound-evoked vibrations of the basilar membrane. We used laser interferometry in vitro and optical coherence tomography in vivo to study the low-frequency part of the guinea pig cochlea, and found that sound stimulation caused motion of a minimal portion of the basilar membrane. Outside the region of peak movement, an exponential decline in motion amplitude occurred across the basilar membrane. The moving region had different dependence on stimulus frequency than the vibrations measured near the mechanosensitive stereocilia. This behavior differs substantially from the behavior found in the extensively studied high-frequency regions of the cochlea.

Keywords: basilar membrane; hair cells; hearing; optical coherence tomography.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Basilar Membrane / physiology*
  • Guinea Pigs
  • Hair Cells, Auditory, Outer / physiology*
  • Hearing / physiology*
  • Interferometry
  • Motion
  • Organ of Corti / cytology
  • Organ of Corti / physiology*
  • Sound
  • Tomography, Optical Coherence