Nuclear Protein of the Testis Midline Carcinoma Masquerading as a Primary Mediastinal Seminoma

Maria S Sayapina; Nikita A Savelov; Apollon I Karseladze; Anatoly A Bulanov; Alexey A Tryakin; Dmitry A Nosov; Avgust M Garin; Sergey A Tjulandin

doi:10.4081/rt.2016.6241

Nuclear Protein of the Testis Midline Carcinoma Masquerading as a Primary Mediastinal Seminoma

Rare Tumors. 2016 Jun 28;8(2):6241. doi: 10.4081/rt.2016.6241.

Authors

Maria S Sayapina¹, Nikita A Savelov², Apollon I Karseladze¹, Anatoly A Bulanov¹, Alexey A Tryakin¹, Dmitry A Nosov¹, Avgust M Garin¹, Sergey A Tjulandin¹

Affiliations

¹ N.N. Blokhin Russian Cancer Research Center , Moscow.
² The Moscow City Oncology Hospital No. 62 , Moscow, Russia.

Abstract

Nuclear protein of the testis (NUT) midline carcinomas are rare aggressive carcinomas characterized by chromosomal rearrangements that involve the gene encoding the NUT. This article reviews the clinicopathologic features and the differential diagnosis of these malignancies.

Keywords: Nuclear protein of the testis midline carcinoma; histone deacetylase inhibitors; primary mediastinal seminoma.

Publication types

Case Reports