Abstract
In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid (CTS). This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in hypertension, pregnancy, and heart and kidney diseases. Novel ouabain-resistant mice that elucidate the key roles of α2 Na+ pumps and their CTS binding site are also discussed.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adrenal Cortex / metabolism*
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Animals
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Blood Pressure Determination / methods
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / physiopathology
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Female
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Humans
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Hypertension / metabolism
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Hypertension / physiopathology*
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Kidney Diseases / metabolism
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Kidney Diseases / physiopathology
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Male
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Mice
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Needs Assessment
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Ouabain / metabolism*
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Sodium-Potassium-Exchanging ATPase / metabolism*
Substances
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Ouabain
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Sodium-Potassium-Exchanging ATPase