Hexafluoro-2-propanol-Promoted Intermolecular Friedel-Crafts Acylation Reaction

Rakesh H Vekariya; Jeffrey Aubé

doi:10.1021/acs.orglett.6b01460

Hexafluoro-2-propanol-Promoted Intermolecular Friedel-Crafts Acylation Reaction

Org Lett. 2016 Aug 5;18(15):3534-7. doi: 10.1021/acs.orglett.6b01460. Epub 2016 Jul 26.

Authors

Rakesh H Vekariya¹, Jeffrey Aubé²

Affiliations

¹ Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66045, United States.
² Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, 125 Mason Farm Road, CB 7363, University of North Carolina , Chapel Hill, North Carolina 27599-7363, United States.

PMID: 27458880
DOI: 10.1021/acs.orglett.6b01460

Abstract

The intermolecular Friedel-Crafts acylation was carried out in hexafluoro-2-propanol to yield aryl and heteroaryl ketones at room temperature without any additional reagents.

Publication types

Research Support, Non-U.S. Gov't