The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.
Keywords: Class III phosphoinositide 3-kinase; Vps34; autophagy; endocytosis; phosphoinositide 3-kinase; phosphorylation/dephosphorylation.
© 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.