The novel PI3K-δ inhibitor TGR-1202 enhances Brentuximab Vedotin-induced Hodgkin lymphoma cell death via mitotic arrest

Leukemia. 2016 Dec;30(12):2402-2405. doi: 10.1038/leu.2016.224. Epub 2016 Aug 8.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brentuximab Vedotin
  • Cell Death / drug effects*
  • Drug Synergism
  • Enzyme Inhibitors / pharmacology*
  • Heterocyclic Compounds, 4 or More Rings / pharmacology*
  • Hodgkin Disease / drug therapy*
  • Hodgkin Disease / pathology
  • Humans
  • Immunoconjugates / pharmacology
  • Immunoconjugates / therapeutic use*
  • Mitosis / drug effects*
  • Phosphoinositide-3 Kinase Inhibitors*

Substances

  • Enzyme Inhibitors
  • Heterocyclic Compounds, 4 or More Rings
  • Immunoconjugates
  • Phosphoinositide-3 Kinase Inhibitors
  • umbralisib
  • Brentuximab Vedotin