Potential Mechanisms Mediating Sustained Weight Loss Following Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

Janine M Makaronidis; Rachel L Batterham

doi:10.1016/j.ecl.2016.04.006

Potential Mechanisms Mediating Sustained Weight Loss Following Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

Endocrinol Metab Clin North Am. 2016 Sep;45(3):539-52. doi: 10.1016/j.ecl.2016.04.006.

Authors

Janine M Makaronidis¹, Rachel L Batterham²

Affiliations

¹ Department of Medicine, Centre for Obesity Research, Rayne Institute, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK; University College London Hospitals (UCLH) Bariatric Centre for Weight Loss, Metabolic and Endocrine Surgery, UCLH, Ground Floor West Wing, 250 Euston Road, London NW1 2PG, UK; National Institute of Health Research University College London Hospitals Biomedical Research Centre, 149 Tottenham Court Road, Kings Cross, London W1T 7DN, UK.
² Department of Medicine, Centre for Obesity Research, Rayne Institute, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK; University College London Hospitals (UCLH) Bariatric Centre for Weight Loss, Metabolic and Endocrine Surgery, UCLH, Ground Floor West Wing, 250 Euston Road, London NW1 2PG, UK; National Institute of Health Research University College London Hospitals Biomedical Research Centre, 149 Tottenham Court Road, Kings Cross, London W1T 7DN, UK. Electronic address: r.batterham@ucl.ac.uk.

PMID: 27519129
DOI: 10.1016/j.ecl.2016.04.006

Abstract

Bariatric surgery is the only effective treatment for severe obesity. Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the most commonly performed procedures, lead to sustained weight loss, improvements in obesity-related comorbidities and reduced mortality. In humans, the main driver for weight loss following RYGB and SG is reduced energy intake. Reduced appetite, changes in subjective taste and food preference, and altered neural response to food cues are thought to drive altered eating behavior. The biological mediators underlying these changes remain incompletely understood but changes in gut-derived signals, as a consequence of altered nutrient and/or biliary flow, are key candidates.

Keywords: Bariatric surgery; Bile acids; Eating behavior; Gut hormones; Microbiome; Obesity; Roux-en-Y gastric bypass; Sleeve gastrectomy.

Publication types

Review

MeSH terms

Energy Intake
Feeding Behavior
Gastrectomy*
Gastric Bypass*
Humans
Obesity, Morbid / surgery*
Weight Loss*

Grants and funding

RP-2015-06-005/DH_/Department of Health/United Kingdom