Abstract
An HIV-infected patient treated with tenofovir disoproxil fumarate/emtricitabine/elvitegravir/cobicistat developed severe acute ischaemia of both legs during a migraine episode. After being interrogated he admitted taking an ergotamine-containing preparation. Ergotism due to interaction between ergotics and cobicistat was diagnosed. We describe the first reported case of this interaction.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adult
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Anti-HIV Agents / administration & dosage
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Anti-HIV Agents / adverse effects*
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Cobicistat / administration & dosage
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Cobicistat / adverse effects*
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Drug Interactions
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Drug Therapy, Combination
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Ergotamine / administration & dosage
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Ergotamine / adverse effects*
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HIV Infections / complications*
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HIV Infections / drug therapy*
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Humans
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Ischemia / etiology*
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Leg
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Male
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Migraine Disorders / complications
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Migraine Disorders / drug therapy
Substances
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Anti-HIV Agents
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Cobicistat
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Ergotamine