Human pluripotent stem cell-derived cardiomyocyte based models for cardiotoxicity and drug discovery

Expert Opin Drug Saf. 2016 Nov;15(11):1455-1458. doi: 10.1080/14740338.2016.1223624. Epub 2016 Sep 9.

Authors

Yimu Zhao¹, Anastasia Korolj^{1

2}, Nicole Feric^{2

3}, Milica Radisic^{1

2

4}

Affiliations

¹ a Department of Chemical Engineering and Applied Chemistry , University of Toronto , Toronto , Ontario , Canada.
² b Institute of Biomaterials and Biomedical Engineering , University of Toronto , Toronto , Ontario , Canada.
³ c TARA Biosystems, Inc ., New York , NY , USA.
⁴ d Toronto General Research Institute , University Health Network, University of Toronto , Toronto , Ontario , Canada.

PMID: 27560951
DOI: 10.1080/14740338.2016.1223624

No abstract available

Keywords: Cardiomyocyte; cardiotoxicity; drug discovery; engineered cardiac tissue; high throughput screening; human pluripotent stem cells.

MeSH terms

Cardiotoxicity / prevention & control*
Drug Design
Drug Discovery / methods*
Drug-Related Side Effects and Adverse Reactions / diagnosis
Drug-Related Side Effects and Adverse Reactions / prevention & control
Humans
Myocytes, Cardiac / cytology*
Myocytes, Cardiac / drug effects
Pluripotent Stem Cells / cytology*