NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors

Leukemia. 2017 Jan;31(1):237-240. doi: 10.1038/leu.2016.250. Epub 2015 Aug 30.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Cell Line
  • Drug Resistance, Neoplasm*
  • Eosinophilia / complications*
  • Humans
  • Infant
  • Mice
  • Mutation
  • Myeloproliferative Disorders / complications
  • Myeloproliferative Disorders / drug therapy*
  • Myeloproliferative Disorders / genetics
  • Oncogene Proteins, Fusion / genetics*
  • Protein Conformation
  • Protein Kinase Inhibitors / pharmacology
  • Protein Kinase Inhibitors / therapeutic use*
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Receptor, Platelet-Derived Growth Factor beta / chemistry
  • Receptor, Platelet-Derived Growth Factor beta / genetics*
  • Sequence Analysis, DNA
  • Transduction, Genetic

Substances

  • Carrier Proteins
  • NDEL1 protein, human
  • NDEL1-PDGFRB oncogene fusion protein, human
  • Oncogene Proteins, Fusion
  • Protein Kinase Inhibitors
  • PDGFRB protein, human
  • Protein-Tyrosine Kinases
  • Receptor, Platelet-Derived Growth Factor beta