The association between the occurrence of Amblyomma variegatum ticks and streptothricosis was studied on the Caribbean island of Antigua. The prevalence of streptothricosis was higher on animals having A. variegatum ticks compared to that of animals not infested with A. variegatum ticks. There was a steady increase in the prevalence of severe lesions as the level of infestation with adult A. variegatum ticks increased. However the distribution of skin lesions could not be related to the predilection feeding sites of adult A. variegatum ticks.