Prognostic value of occult tumor cells obtained by peritoneal lavage in patients with resectable pancreatic cancer and no ascites: A systematic review

J Surg Oncol. 2016 Nov;114(6):743-751. doi: 10.1002/jso.24402. Epub 2016 Sep 19.

Abstract

The poor survival of patients with resectable pancreatic cancer might be related to the presence of occult peritoneal tumor cells (OPTC). This systematic review studies the prognostic value of cytology and carcinoembryonic antigen (CEA) by real-time polymerase chain reaction in peritoneal fluid. The results suggest that presence of OPTC is related to a worse survival in patients with resectable pancreatic cancer. Future studies should investigate its possible role in selecting patients for specific treatment strategies. J. Surg. Oncol. 2016;114:743-751. © 2016 Wiley Periodicals, Inc.

Keywords: CEA; RT-PCR; cytology; occult tumor cells; pancreatic cancer; peritoneal fluid.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / mortality
  • Adenocarcinoma / secondary*
  • Ascitic Fluid / cytology*
  • Ascitic Fluid / metabolism
  • Carcinoembryonic Antigen / metabolism
  • Humans
  • Pancreatectomy
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / pathology*
  • Pancreatic Neoplasms / surgery*
  • Peritoneal Lavage
  • Peritoneal Neoplasms / diagnosis*
  • Peritoneal Neoplasms / metabolism
  • Peritoneal Neoplasms / mortality
  • Peritoneal Neoplasms / secondary*
  • Prognosis
  • Real-Time Polymerase Chain Reaction
  • Survival Rate

Substances

  • Carcinoembryonic Antigen