Circulating 25-hydroxyvitamin D and physical performance in older adults: a nationwide study in Taiwan

Am J Clin Nutr. 2016 Nov;104(5):1334-1344. doi: 10.3945/ajcn.115.122804. Epub 2016 Oct 12.

Abstract

Background: A previous study indicated that 31% of the elderly in Taiwan have a vitamin D deficiency. Vitamin D adequacy has been associated with physical performance in the elderly.

Objectives: The first aim of the current study was to identify the determinants for vitamin D deficiency. The second aim was to evaluate the association between vitamin D status and physical performance.

Design: A total of 5664 community-dwelling participants aged ≥55 y were recruited since 2008. Plasma total 25-hydroxyvitamin D concentrations were originally determined by ELISA and calibrated to a chemiluminescence measurement. Physical performance was assessed by handgrip strength, the Short Physical Performance Battery, timed up and go, a 6-min walk test, and single-leg stands. Multiple linear regression and logistic regression were used to estimate the cross-sectional associations.

Results: Vitamin D inadequacy (<50 nmol/L) was related to higher education (P-trend < 0.01), body mass index [(BMI; in kg/m2) ORs (95% CIs) for ≥30 compared with 18.5 to <25 were 1.78 (1.14, 2.78) for men and 1.53 (1.11, 2.11) for women], and vegetable intake [fourth compared with first quartile, 1.58 (1.15, 2.18) for men and 2.38 (1.82, 3.12) for women]. Higher intakes of fish [fourth compared with first quartile, 0.44 (0.33, 0.59) for men and 0.27 (0.21, 0.36) for women] and milk [fourth compared with first quartile, 0.46 (0.31, 0.69) for men and 0.69 (0.49, 0.95) for women] were associated with lower risk of vitamin D inadequacy. Few subjects had 25-hydroxyvitamin D concentrations <30 nmol/L. Above that concentration, there was no dose-effect relation with physical performance except for single-leg stands.

Conclusions: The factors associated with vitamin D inadequacy in Taiwan were higher education, higher BMI, and lower fish and milk intakes. No dose-effect relation existed between vitamin D concentration and physical performance except for single-leg stands. This study was registered at www.clinicaltrials.gov as NCT02677831.

Keywords: HALST; epidemiology; lifestyle factors; physical performance; vitamin D.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Body Mass Index
  • Calibration
  • Cohort Studies
  • Cross-Sectional Studies
  • Diet
  • Educational Status
  • Female
  • Follow-Up Studies
  • Fruit
  • Hand Strength
  • Humans
  • Linear Models
  • Logistic Models
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Physical Fitness*
  • Quality of Life
  • Seasons
  • Surveys and Questionnaires
  • Taiwan / epidemiology
  • Vegetables
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / epidemiology*

Substances

  • Vitamin D
  • 25-hydroxyvitamin D

Associated data

  • ClinicalTrials.gov/NCT02677831