Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

Derek J Hausenloy; Jose A Barrabes; Hans Erik Bøtker; Sean M Davidson; Fabio Di Lisa; James Downey; Thomas Engstrom; Péter Ferdinandy; Hector A Carbrera-Fuentes; Gerd Heusch; Borja Ibanez; Efstathios K Iliodromitis; Javier Inserte; Robert Jennings; Neena Kalia; Rajesh Kharbanda; Sandrine Lecour; Michael Marber; Tetsuji Miura; Michel Ovize; Miguel A Perez-Pinzon; Hans Michael Piper; Karin Przyklenk; Michael Rahbek Schmidt; Andrew Redington; Marisol Ruiz-Meana; Gemma Vilahur; Jakob Vinten-Johansen; Derek M Yellon; David Garcia-Dorado

doi:10.1007/s00395-016-0588-8

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

Basic Res Cardiol. 2016 Nov;111(6):70. doi: 10.1007/s00395-016-0588-8. Epub 2016 Oct 20.

Authors

Derek J Hausenloy^{1

2

3

4}, Jose A Barrabes⁵, Hans Erik Bøtker⁶, Sean M Davidson⁷, Fabio Di Lisa⁸, James Downey⁹, Thomas Engstrom¹⁰, Péter Ferdinandy^{11

12}, Hector A Carbrera-Fuentes^{13

14

15

16}, Gerd Heusch¹⁷, Borja Ibanez^{18

19}, Efstathios K Iliodromitis²⁰, Javier Inserte⁵, Robert Jennings²¹, Neena Kalia²², Rajesh Kharbanda²³, Sandrine Lecour²⁴, Michael Marber²⁵, Tetsuji Miura²⁶, Michel Ovize^{27

28}, Miguel A Perez-Pinzon^{29

30

31}, Hans Michael Piper³², Karin Przyklenk³³, Michael Rahbek Schmidt¹³, Andrew Redington³⁴, Marisol Ruiz-Meana⁵, Gemma Vilahur³⁵, Jakob Vinten-Johansen³⁶, Derek M Yellon^{7

37}, David Garcia-Dorado³⁸

Affiliations

¹ The Hatter Cardiovascular Institute, University College London, London, UK. derek.hausenloy@duke-nus.edu.sg.
² The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK. derek.hausenloy@duke-nus.edu.sg.
³ Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore. derek.hausenloy@duke-nus.edu.sg.
⁴ National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore. derek.hausenloy@duke-nus.edu.sg.
⁵ Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma, Barcelona, Spain.
⁶ Department of Cardiology, Aarhus University Hospital Skejby, 8200, Aarhus N, Denmark.
⁷ The Hatter Cardiovascular Institute, University College London, London, UK.
⁸ Department of Biomedical Sciences and CNR Institute of Neurosciences, University of Padova, Padua, Italy.
⁹ Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL, USA.
¹⁰ Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
¹¹ Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
¹² Pharmahungary Group, Szeged, Hungary.
¹³ Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, 8 College Road, Singapore, 169857, Singapore.
¹⁴ National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
¹⁵ Institute for Biochemistry, Medical Faculty Justus-Liebig-University, Giessen, Germany.
¹⁶ Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.
¹⁷ Institute for Pathophysiology, West-German Heart and Vascular Center, University of Essen Medical School, Essen, Germany.
¹⁸ Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
¹⁹ IIS-Fundación Jiménez Díaz Hospital, Madrid, Spain.
²⁰ 2nd University Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece.
²¹ Duke University, Durham, NC, USA.
²² Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
²³ Oxford Heart Centre, The John Radcliffe Hospital, Oxford University Hospitals, Oxford, UK.
²⁴ Department of Medicine, Hatter Institute for Cardiovascular Research in Africa and South African Medical Research Council Inter-University Cape Heart Group, Faculty of Health Sciences, University of Cape Town, Chris Barnard Building, Anzio Road, Observatory, Cape Town, Western Cape, 7925, South Africa.
²⁵ King's College London BHF Centre, The Rayne Institute, St. Thomas' Hospital, London, UK.
²⁶ Department of Cardiovascular, Renal, and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
²⁷ Explorations Fonctionnelles Cardiovasculaires, Hôpital Louis Pradel, Lyon, France.
²⁸ UMR 1060 (CarMeN), Université Claude Bernard, Lyon 1, France.
²⁹ Cerebral Vascular Disease Research Laboratories, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
³⁰ Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
³¹ Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
³² Carl von Ossietzky Universität Oldenburg, Ökologiezentrum, Raum 2-116, Uhlhornsweg 99 b, 26129, Oldenburg, Germany.
³³ Department of Physiology and Emergency Medicine, Cardiovascular Research Institute, Wayne State University, Detroit, MI, USA.
³⁴ Division of Cardiology, Department of Pediatrics, Heart Institute, Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
³⁵ Cardiovascular Research Center, CSIC-ICCC, IIB-Hospital Sant Pau, c/Sant Antoni Maria Claret 167, 08025, Barcelona, Spain.
³⁶ Division of Cardiothoracic Surgery, Department of Surgery, Emory University, Atlanta, USA.
³⁷ The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK.
³⁸ Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma, Barcelona, Spain. dgdorado@vhebron.net.

Abstract

To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotection. This article provides an overview of the major topics discussed at this special meeting and underscores the huge importance and impact, the discovery of IPC has made in the field of cardiovascular research.

Keywords: Cardioprotection; Ischaemic conditioning; Mitochondria; Myocardial reperfusion injury; RISK and SAFE pathway.

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

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