Consequences of genetic linkage for the maintenance of sexually antagonistic polymorphism in hermaphrodites

Abstract

When selection differs between males and females, pleiotropic effects among genes expressed by both sexes can result in sexually antagonistic selection (SA), where beneficial alleles for one sex are deleterious for the other. For hermaphrodites, alleles with opposing fitness effects through each sex function represent analogous genetic constraints on fitness. Recent theory based on single-locus models predicts that the maintenance of SA genetic variation should be greatly reduced in partially selfing populations. However, selfing also reduces the effective rate of recombination, which should facilitate selection on linked allelic combinations and expand opportunities for balancing selection in a multilocus context. Here, I develop a two-locus model of SA selection for simultaneous hermaphrodites, and explore the joint influence of linkage, self-fertilization, and dominance on the maintainance of SA polymorphism. I find that the effective reduction in recombination caused by selfing significantly expands the parameter space where SA polymorphism can be maintained relative to single-locus models. In particular, linkage facilitates the invasion of male-beneficial alleles, partially compensating for the "female-bias" in the net direction of selection created by selfing. I discuss the implications of accounting for linkage among SA loci for the maintenance of SA genetic variation and mixed mating systems in hermaphrodites.

Keywords: Balancing selection; genetic linkage; intralocus sexual conflict; mixed mating systems; recombination; two-locus model.