The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

Cailyn H Spurrell; Diane E Dickel; Axel Visel

doi:10.1016/j.cell.2016.10.054

The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

Cell. 2016 Nov 17;167(5):1163-1166. doi: 10.1016/j.cell.2016.10.054.

Authors

Cailyn H Spurrell¹, Diane E Dickel¹, Axel Visel²

Affiliations

¹ MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
² MS 84-171, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA; School of Natural Sciences, University of California, Merced, CA 95343, USA. Electronic address: avisel@lbl.gov.

Abstract

Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. In this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specific dynamics of interactions between regulators and gene promoters.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Disease / genetics
Enhancer Elements, Genetic*
Epigenomics
Gene Expression Regulation
Humans
Organ Specificity
Promoter Regions, Genetic*

Abstract

Publication types

MeSH terms

Grants and funding