4-hydroxynonenal-mediated signaling and aging

Free Radic Biol Med. 2017 Oct:111:219-225. doi: 10.1016/j.freeradbiomed.2016.11.032. Epub 2016 Nov 20.

Abstract

4-Hydroxy-2-nonenal (HNE), one of the major α, β-unsaturated aldehydes produced during lipid peroxidation, is a potent messenger in mediating signaling pathways. Lipid peroxidation and HNE production appear to increase with aging. Although the cause and effect relation remains arguable, aging is associated with significant changes in diverse signaling events, characterized by enhanced or diminished responses of specific signaling pathways. In this review we will discuss how HNE may contribute to aging-related alterations of signaling pathways.

Keywords: 4-Hydroxynoneal; Aging; HNE; Oxidative stress; Redox signaling.

Publication types

  • Review

MeSH terms

  • AMP-Activated Protein Kinases / genetics
  • AMP-Activated Protein Kinases / metabolism
  • Aging / genetics
  • Aging / metabolism*
  • Aldehydes / metabolism*
  • Animals
  • Cytokines / genetics
  • Cytokines / metabolism
  • Gene Expression Regulation*
  • Humans
  • I-kappa B Kinase / genetics
  • I-kappa B Kinase / metabolism
  • Lipid Peroxidation
  • NF-E2-Related Factor 2 / genetics
  • NF-E2-Related Factor 2 / metabolism
  • NF-kappa B / genetics
  • NF-kappa B / metabolism
  • Oxidative Stress
  • Proto-Oncogene Proteins c-akt / genetics
  • Proto-Oncogene Proteins c-akt / metabolism
  • Signal Transduction*
  • TOR Serine-Threonine Kinases / genetics
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • Aldehydes
  • Cytokines
  • NF-E2-Related Factor 2
  • NF-kappa B
  • NFE2L2 protein, human
  • MTOR protein, human
  • Proto-Oncogene Proteins c-akt
  • TOR Serine-Threonine Kinases
  • I-kappa B Kinase
  • AMP-Activated Protein Kinases
  • 4-hydroxy-2-nonenal