Invasive cutaneous infection due to Scopulariopsis brevicaulis unsuccessfully treated with high-dose micafungin in a neutropenic patient

Infection. 2017 Jun;45(3):361-363. doi: 10.1007/s15010-016-0971-2. Epub 2016 Dec 1.

Abstract

Scopulariopsis brevicaulis onychomycosis with local cutaneous invasion was diagnosed in an acute leukemia patient and unsuccessfully treated with high-dose micafungin, based on antifungal susceptibility testing. This case should alert clinicians to the possible severe evolution of onychomycosis in neutropenic patients and suggests that surgery should be preferred in such a situation.

Keywords: Febrile neutropenia; Immunocompromised; Invasive fungal infection; Micafungin; Onychomycosis; Scopulariopsis spp..

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antifungal Agents / therapeutic use
  • Dermatomycoses / complications
  • Dermatomycoses / diagnosis
  • Dermatomycoses / drug therapy
  • Dermatomycoses / immunology
  • Echinocandins / therapeutic use*
  • Female
  • Foot Dermatoses / complications
  • Foot Dermatoses / diagnosis
  • Foot Dermatoses / drug therapy*
  • Foot Dermatoses / immunology
  • Humans
  • Immunocompromised Host*
  • Lipopeptides / therapeutic use*
  • Micafungin
  • Neutropenia / complications*
  • Neutropenia / immunology
  • Onychomycosis / complications*
  • Onychomycosis / diagnosis
  • Onychomycosis / drug therapy*
  • Onychomycosis / immunology
  • Scopulariopsis / physiology*
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Micafungin