Successful T-cell Replete Hematopoietic Stem Cell Boost Without Conditioning for Late Graft Failure

Transplant Proc. 2016 Nov;48(9):3225-3226. doi: 10.1016/j.transproceed.2016.06.035.

Abstract

Late graft failure is a rare but significant complication after allogeneic stem cell transplantation, which is often complicated by severe infections. We report a case of late graft failure, which was successfully treated with a T-cell replete hematopoietic stem cell boost without conditioning that induced rapid engraftment and relieved the patient of infection. Discontinuation of immunosuppressants and nilotinib administration suppressed the host cells. Achieving full donor chimerism allowed us to administer a peripheral blood stem cell boost without conditioning.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Graft vs Host Disease / surgery*
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / methods*
  • Hematopoietic Stem Cells
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Reoperation*
  • Transplantation Conditioning
  • Transplantation, Homologous

Substances

  • Immunosuppressive Agents