Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function

Natalie A Bello; Hyacinth I Hyacinth; Nicholas S Roetker; Samantha R Seals; Rakhi P Naik; Vimal K Derebail; Abhijit V Kshirsagar; Nigel S Key; James G Wilson; Adolfo Correa; Robert J Adams; Leonard D Egede; W T Longstreth Jr; Gaurav Choudhary; Beatrice E Gee; Austin L Hughes; Amil M Shah; JoAnn E Manson; Matthew Allison; Gregory L Burke; Aaron R Folsom; Cara L Carty; Alexander P Reiner; Scott D Solomon; Suma H Konety

doi:10.1182/blood-2016-08-705541

Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function

Blood. 2017 Feb 9;129(6):799-801. doi: 10.1182/blood-2016-08-705541. Epub 2016 Dec 8.

Authors

Natalie A Bello^{1

2}, Hyacinth I Hyacinth³, Nicholas S Roetker⁴, Samantha R Seals⁵, Rakhi P Naik⁶, Vimal K Derebail⁷, Abhijit V Kshirsagar⁷, Nigel S Key⁷, James G Wilson⁸, Adolfo Correa^{9

10}, Robert J Adams¹¹, Leonard D Egede¹⁰, W T Longstreth Jr¹², Gaurav Choudhary¹³, Beatrice E Gee¹⁴, Austin L Hughes¹⁵, Amil M Shah², JoAnn E Manson², Matthew Allison¹⁶, Gregory L Burke¹⁷, Aaron R Folsom⁴, Cara L Carty¹⁸, Alexander P Reiner¹⁸, Scott D Solomon², Suma H Konety¹⁹

Affiliations

¹ Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY.
² Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
³ Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.
⁴ Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN.
⁵ Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS.
⁶ Division of Hematology, Johns Hopkins School of Medicine, Baltimore, MD.
⁷ Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁸ Department of Physiology and Biophysics, and.
⁹ Department of Medicine, University of Mississippi Medical Center, Jackson, MS.
¹⁰ Department of Medicine, and.
¹¹ Department of Neurology, Medical University of South Carolina, Charleston, SC.
¹² Department of Neurology and Department of Epidemiology, University of Washington, Seattle, WA.
¹³ Providence VA Medical Center, Brown University, Providence, RI.
¹⁴ Department of Pediatrics, Morehouse School of Medicine, Atlanta, GA.
¹⁵ Department of Biology, University of South Carolina, Columbia, SC.
¹⁶ Division of Preventive Medicine, University of California San Diego, San Diego, CA.
¹⁷ Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
¹⁸ Fred Hutchinson Cancer Research Center, Seattle, WA; and.
¹⁹ Division of Cardiology, University of Minnesota Medical Center, Minneapolis, MN.

Abstract

Publisher's Note: There is an Inside Blood Commentary on this article in this issue.

Publication types

Letter
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Black or African American / genetics
Female
Heart Diseases / etiology*
Heart Diseases / pathology
Heart Failure / etiology*
Heterozygote
Humans
Male
Risk Factors
Sickle Cell Trait / complications*
Sickle Cell Trait / genetics

Abstract

Publication types

MeSH terms

Grants and funding