Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp

J Antibiot (Tokyo). 1989 Sep;42(9):1344-9. doi: 10.7164/antibiotics.42.1344.

Abstract

Three antioxidant isoflavonoids characterized as 4',7,8-trihydroxyisoflavone (1), 3',4',7-trihydroxyisoflavone (2) and 8-chloro-3',4',5,7-tetrahydroxyisoflavone (3) were isolated from the cultured broth of Streptomyces sp. OH-1049. Among them, 3 is a novel isoflavonoid possessing a chlorine atom in the molecule. In in vitro studies, these antibiotics were found to possess antioxidant activity whereas showed almost no cytocidal activities against HeLa S3 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology
  • Fermentation
  • Flavonoids / isolation & purification*
  • HeLa Cells / drug effects
  • Isoflavones / isolation & purification*
  • Isoflavones / pharmacology
  • Male
  • Microbial Sensitivity Tests
  • Rats
  • Rats, Inbred Strains
  • Streptomyces / classification
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Antioxidants
  • Flavonoids
  • Isoflavones
  • 8-chloro-3',4',5,7-tetrahydroxyisoflavone
  • 4',7,8-trihydroxyisoflavone
  • 3',4',7-trihydroxyisoflavone