All-trans retinoic acid (ATRA) in non-promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low-dose Ara-C in three elderly patients with NPM1-mutated AML unfit for intensive chemotherapy and review of the literature

Fabio Forghieri; Sara Bigliardi; Chiara Quadrelli; Monica Morselli; Leonardo Potenza; Ambra Paolini; Elisabetta Colaci; Patrizia Barozzi; Patrizia Zucchini; Giovanni Riva; Daniela Vallerini; Ivana Lagreca; Roberto Marasca; Franco Narni; Adriano Venditti; Maria Paola Martelli; Brunangelo Falini; Francesco Lo Coco; Sergio Amadori; Mario Luppi

doi:10.1002/ccr3.723

All-trans retinoic acid (ATRA) in non-promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low-dose Ara-C in three elderly patients with NPM1-mutated AML unfit for intensive chemotherapy and review of the literature

Clin Case Rep. 2016 Oct 24;4(12):1138-1146. doi: 10.1002/ccr3.723. eCollection 2016 Dec.

Authors

Fabio Forghieri¹, Sara Bigliardi¹, Chiara Quadrelli¹, Monica Morselli¹, Leonardo Potenza¹, Ambra Paolini¹, Elisabetta Colaci¹, Patrizia Barozzi¹, Patrizia Zucchini¹, Giovanni Riva¹, Daniela Vallerini¹, Ivana Lagreca¹, Roberto Marasca¹, Franco Narni¹, Adriano Venditti², Maria Paola Martelli³, Brunangelo Falini³, Francesco Lo Coco⁴, Sergio Amadori², Mario Luppi¹

Affiliations

¹ Department Medical and Surgical Sciences Section of Hematology Azienda Ospedaliero-Universitaria Policlinico University of Modena and Reggio Emilia Modena Italy.
² Department of Hematology University Tor Vergata Rome Italy.
³ Institute of Hematology CREO (Centro di Ricerca Emato-Oncologico) Ospedale S. Maria della Misericordia, S. Andrea delle Fratte University of Perugia Perugia Italy.
⁴ Department of Biomedicine and Prevention University Tor Vergata Rome Italy.

Abstract

Based upon the clinical behavior of three patients, we suggest that the combination of low-dose Ara-C and all-trans retinoic acid may potentially be effective in some elderly patients, unfit for intensive chemotherapy, affected with NPM1-mutated acute myeloid leukemia without FLT3 mutations, warranting perspective clinical studies in these selected patients.

Keywords: All‐trans retinoic acid; NPM1‐mutated acute myeloid leukemia; elderly patients; low‐dose Ara‐C; unfitness for intensive chemotherapy.

Publication types

Case Reports