Abstract
We present a case of hepatosplenic necrotizing sarcoid granulomatosis, a variant form of "classical" sarcoidosis, that became clinically apparent in the form of multiple hepatic and splenic masses mimicking malignancy. Flow cytometry of intrahepatic T cells isolated from liver biopsy led to the targeted treatment with anti-tumor necrosis factor-alpha, which was highly effective in inducing remission. (Hepatology 2017;65:1410-1412).
© 2016 by the American Association for the Study of Liver Diseases.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Biopsy, Needle
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Granuloma / diagnostic imaging
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Granuloma / drug therapy*
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Granuloma / pathology*
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Humans
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Immunohistochemistry
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Infliximab / administration & dosage*
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Infusions, Intravenous
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Liver Diseases / diagnostic imaging*
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Liver Diseases / drug therapy*
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Liver Diseases / pathology
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Magnetic Resonance Imaging / methods
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Male
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Necrosis / pathology
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Prognosis
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Sarcoidosis / diagnostic imaging
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Sarcoidosis / drug therapy*
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Sarcoidosis / pathology
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Treatment Outcome
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
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Tumor Necrosis Factor-alpha
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Infliximab