MetaboSignal: a network-based approach for topological analysis of metabotype regulation via metabolic and signaling pathways

Bioinformatics. 2017 Mar 1;33(5):773-775. doi: 10.1093/bioinformatics/btw697.

Abstract

Summary: MetaboSignal is an R package that allows merging metabolic and signaling pathways reported in the Kyoto Encyclopaedia of Genes and Genomes (KEGG). It is a network-based approach designed to navigate through topological relationships between genes (signaling- or metabolic-genes) and metabolites, representing a powerful tool to investigate the genetic landscape of metabolic phenotypes.

Availability and implementation: MetaboSignal is available from Bioconductor: https://bioconductor.org/packages/MetaboSignal/.

Contact: m.dumas@imperial.ac.uk .

Supplementary information: Supplementary data are available at Bioinformatics online.

MeSH terms

  • Adipose Tissue / metabolism
  • Animals
  • Computational Biology / methods*
  • Metabolic Networks and Pathways*
  • Quantitative Trait Loci
  • Rats
  • Signal Transduction*
  • Software*