HLA-DQA1 and HLA-DQB1 allele diversity and its extended haplotypes in Madeira Island (Portugal)

H Spínola; A Lemos; A R Couto; B Parreira; M Soares; I Dutra; J Bruges-Armas; A Brehm

doi:10.1111/iji.12300

HLA-DQA1 and HLA-DQB1 allele diversity and its extended haplotypes in Madeira Island (Portugal)

Int J Immunogenet. 2017 Feb;44(1):27-31. doi: 10.1111/iji.12300. Epub 2016 Dec 29.

Authors

H Spínola¹, A Lemos¹, A R Couto^{2

3}, B Parreira^{2

3}, M Soares^{2

3}, I Dutra^{2

3}, J Bruges-Armas^{2

3}, A Brehm¹

Affiliations

¹ Human Genetics Laboratory, University of Madeira, Funchal, Portugal.
² SEEBMO, Hospital Santo Espírito de Angra do Heroísmo, Azores, Portugal.
³ Genetics and Arthritis Research Group - I3S, University of Porto, Porto, Portugal.

PMID: 28032448
DOI: 10.1111/iji.12300

Abstract

This study shows, for the first time, high-resolution allele frequencies of HLA-DQA1 loci in Madeira Island (Portugal) and allows us to better understand and refine present knowledge on DQB1 variation, with the identification of several alleles not previously reported in this population. Estimates on haplotype profile, involving HLA-A, HLA-B, HLA-DRB1, HLA-DQA1 and HLA-DQB1, are also reported.

MeSH terms

Alleles
Female
Gene Expression
Gene Frequency*
Genetic Variation*
HLA-A Antigens / genetics
HLA-A Antigens / immunology
HLA-B Antigens / genetics
HLA-B Antigens / immunology
HLA-DQ alpha-Chains / genetics*
HLA-DQ alpha-Chains / immunology
HLA-DQ beta-Chains / genetics*
HLA-DQ beta-Chains / immunology
HLA-DRB1 Chains / genetics
HLA-DRB1 Chains / immunology
Haplotypes*
Humans
Male
Portugal

Substances

HLA-A Antigens
HLA-B Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DQA1 antigen
HLA-DQB1 antigen
HLA-DRB1 Chains