Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment With Erlotinib

Clin Genitourin Cancer. 2017 Aug;15(4):e727-e734. doi: 10.1016/j.clgc.2016.11.001. Epub 2016 Dec 1.
No abstract available

Keywords: EGFR; Exome; Genome; Transcriptome; Urethral adenocarcinoma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma, Mucinous / drug therapy*
  • Adenocarcinoma, Mucinous / genetics
  • Aged
  • ErbB Receptors / genetics*
  • Erlotinib Hydrochloride / administration & dosage*
  • Erlotinib Hydrochloride / therapeutic use
  • Gene Amplification
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Neoplasm Metastasis
  • Precision Medicine
  • Sequence Analysis, DNA / methods*
  • Up-Regulation
  • Urethral Neoplasms / drug therapy*
  • Urethral Neoplasms / genetics

Substances

  • Erlotinib Hydrochloride
  • EGFR protein, human
  • ErbB Receptors